There is growing awareness that ASD has several comorbidities with gastrointestinal disorders and altered microbiota and that host-microbiota alterations may contribute to disease symptoms. Here we explored the interactions between the gut microbiota, gut physiology and social behavior in a mouse model of ASD. We observed a decrease in the relative abundance of bacterial species in the gut of ASD mice in particular Bifidobacterium and Blautia associated with a deficit in bile acid and Tryptophan metabolism, marked gastrointestinal dysfunction and altered social interactions among ASD animals. Blautia have been shown to modulate 5HT metabolism by increasing Tph1 expression in the gut activating 5HT and intestinal motility.
Year: 2017
Nationality: Ireland
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