In this study, we investigated the difference in gut microbiota between patients with epilepsy and a group of healthy volunteers. Therefore, we revealed the role of microbiota in the etiology of epilepsy to help develop new therapeutic approaches. We observed taxonomic drift in gut microbiota of patients with epilepsy and significant differences between them and healthy volunteers.
Proteobacteria and Fusobacteria, which caused autoimmune diseases and inflammation in the intestines in patients with epilepsy, were significantly elevated compared to the healthy group. Firmicutes, Bacteroidetes and Actinobacteri, which had a positive effect on the immune system of the intestine and the central nervous system by producing short-chain fatty acids, were significantly decreased in patients with epilepsy compared to the healthy group, demonstrating that autoimmune mechanisms and inflammation may play a role in the etiology of epilepsy.
Year: 2020
Nationality: Türkiye
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