Commensal bacteria are crucial for the development and maintenance of a healthy immune system and intestinal epithelial cells (IECs) play a central role in the host-microbiota dialogue by inducing early microbe-derived immune signals. IDO-1 (Indoleamine 2,3-dioxygenase-1) is among several effector molecules that modulate IEC-induced immune responses. The impact of individual culturable commensal bacteria on IDO-1 transcriptional expression was studied and butyrate was found to be the major metabolite controlling IDO-1 expression in primary human IEC cell lines. Furthermore, butyrate alters IDO-1 transcription in a STAT-1-independent manner (due to histone deacetylase inhibition). In conclusion, IDO-1 expression is down-regulated by butyrate through STAT-1 reduction and through histone deacetylase inhibitory properties.
Year: 2018
Nationality: France
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