A growing body of evidence suggests that diet is an important contributing factor in the development, management and prevention of a number of psychiatric illnesses. Anorexia nervosa (AN) is associated with high levels of psychiatric comorbidity (psychosis, hyperactivity, depression and anxiety) and has high mortality. Evidence suggests that excessive dieting and/or food restriction may precipitate brain tryptophan (Trp) and serotonin. The aim is to evaluate Trp supplementation in improving therapies in patients with AN.
Nutritional deficiency of Trp may reduce SSRI-induced enhancement of serotonin neurotransmission and their therapeutic effects. It may also reduce the efficacy of antipsychotic drugs.
Trp administration accelerated the healing of gastroduodenal ulcers in patients treated with omeprazole.
Year: 2017
Nationality: Pakistan