This review reviews the literature of the last decade on the involvement of immunological mechanisms in normal brain development, as well as its role in Tourette's syndrome, connective tissue diseases (CTD) and related neuropsychiatric disorders (OCD and ADHD). Immunological pathways are implicated in several early neurodevelopmental processes, including the formation and refinement of neuronal circuits. Hyperactivity of systemic immune pathways and neuroinflammation may contribute to fluctuations in the main behavioral features of CTD, OCD and ADHD.
Year: 2020
Nationality: USA
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