Rett syndrome is often associated with gastrointestinal dysfunction and constipation suggesting a link between RTT gastrointestinal abnormalities and gut microbiota. The aim of this study was to evaluate bacterial and fungal gut microbiota in a cohort of RTT subjects integrating clinical metabolomic aspects to understand whether changes in gut microbiota of RTT subjects could be associated with gastrointestinal abnormalities and inflammatory states. Conclusions: The gut microbiota of RTT subjects is dysbiotic both for bacteria and fungi.
This suggests that impairments in MeCP2 gene function favor the establishment of an adapted microbial community and associated alteration of SCFAs could reinforce the constipation state of RTT subjects and contribute to gastrointestinal pathophysiology.
Year: 2016
Nationality: Italy
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