We discuss how age-related kynurenine/tryptophan (Kyn/Trp) activation is required to control inflammation and alters the function of other Trp pathways. Inflammation indeed diverts Trp metabolism towards its immunomodulatory catabolite Kyn. Alterations in other Trp metabolites may drive aging and underlie the pathophysiology of age-related diseases. Age-related decline in tissue homeostasis results in a physiological low-grade chronic inflammatory phenotype that is implicated in many age-related diseases. Systemic Trp and Kyn levels change with aging and in age-related diseases, furthermore modulation of Trp metabolism may cause treatment-related inflammation-related diseases.
Year: 2019
Nationality: Australia
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