Item has been added

Skip to content

For your health and well-being

Reliability and innovation at the service of your health.

🚛 FREE SHIPPING for orders over €25 🚛

Get in touch with us!

Freek JH Sorgdrager et al.

Tryptophan metabolism in inflammaging: from biomarker to therapeutic target

Frontiers in Immunology

Freek J. H. Sorgdrager et al.   <br> <br>Tryptophan metabolism in inflammaging: from biomarker to therapeutic target  <br>  <br>  Frontiers in Immunology

We discuss how age-related kynurenine/tryptophan (Kyn/Trp) activation is required to control inflammation and alters the function of other Trp pathways. Inflammation indeed diverts Trp metabolism towards its immunomodulatory catabolite Kyn. Alterations in other Trp metabolites may drive aging and underlie the pathophysiology of age-related diseases. Age-related decline in tissue homeostasis results in a physiological low-grade chronic inflammatory phenotype that is implicated in many age-related diseases. Systemic Trp and Kyn levels change with aging and in age-related diseases, furthermore modulation of Trp metabolism may cause treatment-related inflammation-related diseases.

Year: 2019

Nationality: Australia

Download the document