The gut microbiome differs between typically developing (TD) and autism spectrum disorder (ASD) individuals, although it is unclear whether the microbiome contributes to symptoms.
They transplanted gut microbiota from human donors with ASD or TD controls into germ-free mice and revealed that colonization with ASD microbiota is sufficient to induce characteristic autistic behaviors. The brains of mice colonized with ASD microbiota show alternative splicing of ASD-relevant genes.
Microbiome and metabolome profiles of mice harboring human microbiota predict that specific bacterial taxa and their metabolites modulate ASD behaviors.
Year: 2019
Nationality: USA
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