Review that aims to shed light on the potential influence of the microbiome on the development of the most common neurodevelopmental disorder, ADHD. The etiology and pathophysiology of ADHD are still unclear and it is a challenge to find biomarkers of the disorder.
We focused on factors that have been associated with a higher risk of developing ADHD, simultaneously influencing the microbial composition. We examined the effect of a different microbial composition on the concentrations of neurotransmitters involved in the pathophysiology of ADHD and deduced factors that are related to high ADHD prevalence and that influence the gut microbiota such as: emergency caesarean sections, premature births.
Nutritional influences (breastfeeding, SCFA ingestion, etc.) on the microbiome and ADHD have also been evaluated and therefore as a potential therapy for the disorder. In fact, it has been seen that the concentration of brain-derived neurotrophic factor (BDNF) is indirectly influenced by the microbiota and plays a fundamental role in ADHD pathogenesis: negative correlation between BDNF levels and ADHD as SCFA and PUFA levels are positively correlated with BDNF, making SCFA could be a useful means for treating ADHD symptoms through microbiota modification.
Year: 2019
Nationality: Switzerland
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